Peripherally inserted central catheter Innovation to reduCe Infections and Clots (the PICNIC trial)
Peripherally inserted central catheters (PICCs) play a significant role in modern healthcare, >140,000 PICCs are used by patients in Australia each year to receive anti-cancer agents, anti-microbials, hydration, nutrition, and for repeated blood tests. However PICC complications are rife - 30% of PICCs are associated with serious complication and fail prior to treatment completion. These complications include deep vein thrombosis (DVT) (Chopra, V. et al., 2013) and catheter-associated bloodstream infection (CABSI), and result in treatment delays, high healthcare costs, morbidity and mortality. Innovative PICC antimicrobial and "non-stick" materials may hold the key to reducing preventable harm associated with PICC use.
The PICNIC trial is a multi-centre, superiority randomised controlled trial (RCT) will evaluate the effectiveness of two innovative PICC materials and design to prevent PICC failure. This trial builds from the evidence established in PICCOMPARE (Kleidon T et al. 2018) (Ullman A et al., 2018) . PICNIC will evaluate the effectiveness of an (i) anti-thrombogenic and (ii) anti-microbial PICCs against standard care (non-valved power injectable polyurethane catheters). Three Queensland tertiary hospitals will be involved in recruiting participants from both Medical and Surgical units, including paediatric and adult cohorts. 1150 participants will be recruited over a two year period, with an eight weeks follow-up period (or until catheter failure). The PICNIC trial will also examine PICC related cost-effectiveness, haematological and microbiological endpoints against traditional polyurethane PICCs.
The PICNIC trial has been funded by a NHMRC grant, for more information please contact Ms Deanne August or Dr Amanda Ullman (Griffith University), Dr Rachel Walker (Princess Alexandra Hospital) Ms Tricia Kleidon (Queensland Children's Hospital), or Ms Nicole Marsh (Royal Brisbane and Women's Hospital).
Investigation Team:
Associate Professor Amanda Ullman, Griffith University; Doctor Patrick Harris, The University of Queensland; Associate Professor Andrew Bulmer, Griffith University; Doctor Rachel Walker, Griffith University; Doctor Naomi Runnegar, Princess Alexandra Hospital; Ms Tricia Kleidon, Queensland Children's Hospital; Doctor Paul Lee-Archer, Queensland Children's Hospital; Doctor Ben Pearch, Princess Alexandra Hospital; Ms Deanne August, Griffith University
Ms Cathy Biles, Princess Alexandra Hospital; Associate Professor Joshua Byrnes, Griffith University; Professor Vineet Chopra, University of Michigan; Professor Alan Coulthard, Royal Brisbane and Women's Hospital; Ms Nicole Marsh, Royal Brisbane and Women's Hospital/Griffith University; Ms Katrina Southham, Royal Brisbane and Women's Hospital/Metro North; Professor Rob Ware, Griffith University; Associate Professor Peter Mollee, Princess Alexandra Hospital; Professor Claire Rickard, Griffith University; Professor Marianne Wallis, University of the Sunshine Coast.
https://www.tandfonline.com/doi/full/10.1080/17434440.2019.1555466
https://www.ncbi.nlm.nih.gov/pubmed/29649341
https://www.ncbi.nlm.nih.gov/pubmed/23697825
Chopra, V., et al., Risk of venous thromboembolism associated with peripherally inserted central catheters: systematic review and meta-analysis. Lancet, 2013. 382(9889): p. 311-25.
